Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate
January 1976
in “
Vitamins and hormones
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary This chapter discusses androgen receptors and protein synthesis in the prostate, reporting that DHT-dependent receptor protein translocation increases protein-synthesizing activity after androgen injection in rat models. Our plain-language summary of this paper — not a Tressless recommendation.
The chapter described the presence of two proteins in the cytosol fraction of the ventral prostate that preferentially bind to dihydrotestosterone (DHT) over other natural steroids, with one also binding to estradiol but not cortisol. These complexes can be separated using ammonium sulfate fractionation or Sephadex gel chromatography. In castrated rats, prostate cell nuclei have few proteins that bind steroids specifically, but a DHT-protein complex appears after testosterone or DHT injection. This complex's movement to the cell nuclei is temperature-dependent. Additionally, prostate ribosomes from androgen-injected rats show increased protein synthesis compared to controls, likely due to an increase in mRNA content in the ribosomal fractions.
