Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate

    January 1976 in “ Vitamins and hormones ”
    Shutsung Liao, John L Tymoczko, Evangelina Castañeda, Tehming Liang
    TLDR Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.
    The chapter described the presence of two proteins in the cytosol fraction of the ventral prostate that preferentially bind to dihydrotestosterone (DHT) over other natural steroids, with one also binding to estradiol but not cortisol. These complexes can be separated using ammonium sulfate fractionation or Sephadex gel chromatography. In castrated rats, prostate cell nuclei have few proteins that bind steroids specifically, but a DHT-protein complex appears after testosterone or DHT injection. This complex's movement to the cell nuclei is temperature-dependent. Additionally, prostate ribosomes from androgen-injected rats show increased protein synthesis compared to controls, likely due to an increase in mRNA content in the ribosomal fractions.
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