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Glossary Prostate

small gland in males producing seminal fluid for sperm transport

The prostate is a small, walnut-sized gland in males located just below the bladder and in front of the rectum. It produces seminal fluid, which nourishes and transports sperm during ejaculation. This gland plays a crucial role in male reproductive health, and its enlargement or dysfunction can lead to conditions such as benign prostatic hyperplasia (BPH) or prostate cancer.

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Research

5 / 1000+ results

research DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

235 citations , September 2004 in “The Journal of urology/The journal of urology”

This review discusses the role of dihydrotestosterone in benign prostatic hyperplasia and reports no new results; the authors highlight 5alpha-reductase inhibitors as a well-established treatment option.

research ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

224 citations , February 2013 in “The Journal of clinical investigation/The journal of clinical investigation”

This study identifies SOX9 as a critical downstream effector of ERG in TMPRSS2:ERG fusion-positive prostate cancer, indicating its role in tumor invasion and growth.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

research A Review on the Clinical Utility of PSA in Cancer Prostate

154 citations , March 2012 in “Indian Journal of Surgical Oncology”

This review re-evaluates the role of Serum Prostate Specific Antigen in prostate cancer diagnosis, suggesting it is most reliable for detecting cancer recurrences after treatment.

research Understanding the Epidemiology, Natural History, and Key Pathways Involved in Prostate Cancer

153 citations , April 2009 in “Urology”

This article reviews potential prevention and intervention strategies for prostate cancer, including 5alpha-reductase inhibition, but reports no new clinical findings.

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Community Join

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community Prostate aches on oral finasteride

in Finasteride/Dutasteride 6 upvotes 1 month ago

The conversation discusses prostate aches experienced by someone taking oral finasteride for hair loss, with users suggesting the aches may be due to prostate size reduction. Some users share similar experiences, while others express skepticism about the side effects.

community Fin effects on prostate sensation for MSM

5 upvotes 4 years ago

Finasteride may affect prostate sensation and size, with some users reporting easier urination. Concerns exist about prostate shrinkage even at lower doses.

community Finasteride linked to CPPS or Prostate issues

9 upvotes 4 days ago

community Finasteride weird side effects: slight discomfort in lower abdomen/bladder/prostate

in Finasteride 135 upvotes 1 year ago

The user experienced bladder and prostate discomfort after taking finasteride and stopped the medication, but symptoms returned upon resuming at a lower dose. The doctor suggested trying dutasteride as an alternative.

community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 9 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

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