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    Glossary Prostate

    small gland in males producing seminal fluid for sperm transport

    The prostate is a small, walnut-sized gland in males located just below the bladder and in front of the rectum. It produces seminal fluid, which nourishes and transports sperm during ejaculation. This gland plays a crucial role in male reproductive health, and its enlargement or dysfunction can lead to conditions such as benign prostatic hyperplasia (BPH) or prostate cancer.

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    1. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    2. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer 2013 · 224 citations
    3. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    4. A Review on the Clinical Utility of PSA in Cancer Prostate Indian Journal of Surgical Oncology · 2012 · 154 citations
    5. Understanding the Epidemiology, Natural History, and Key Pathways Involved in Prostate Cancer Urology · 2009 · 153 citations
    6. Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted <sup>99m</sup>Tc-Radioimaging Agents Molecular Pharmaceutics · 2009 · 148 citations
    7. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    8. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer Communications biology · 2020 · 113 citations
    9. Epidemiology and treatment modalities for the management of benign prostatic hyperplasia Translational Andrology and Urology · 2019 · 110 citations
    10. 5α‐Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009 · 93 citations
    11. Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice Journal of Biological Chemistry · 2004 · 91 citations
    12. Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial Lancet Oncology · 2006 · 89 citations
    13. Selenium and vitamin E supplements for prostate cancer: evidence or embellishment? Urology · 2002 · 76 citations
    14. The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen and Sexual Function in Healthy Young Men 2008 · 72 citations
    15. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    16. Prostate cancer prevention Cancer · 2007 · 71 citations
    17. Prostate Cancer Early Detection, Version 2.2015 Journal of the National Comprehensive Cancer Network · 2015 · 67 citations
    18. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate Vitamins and hormones · 1976 · 59 citations
    19. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    20. The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications The Prostate · 1986 · 57 citations
    21. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells American journal of physiology. Cell physiology · 2006 · 56 citations
    22. Liarozole—a novel treatment approach for advanced prostate cancer: results of a large randomized trial versus cyproterone acetate Urology · 1998 · 52 citations
    23. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    24. The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model Biology direct · 2010 · 50 citations
    25. Prostate cancer incidence among finasteride and alpha-blocker users in the Finnish Prostate Cancer Screening Trial British Journal of Cancer · 2009 · 49 citations
    26. 5-α-Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review BJUI · 2010 · 44 citations
    27. Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia Food and chemical toxicology · 2012 · 44 citations
    28. A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer PLOS Genetics · 2020 · 43 citations
    29. Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase Scientific Reports · 2016 · 43 citations
    30. Male pattern baldness and the risk of prostate cancer Annals of Oncology · 2011 · 38 citations