The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

    January 2003 in “ American Journal of Pathology
    Barbara Comuzzi, Leonidas Lambrinidis, Hermann Rogatsch, Sonia Godoy-Tundidor, Nikola Knezevic, Ivan Krhen, Zvonimir Mareković, Georg Bartsch, Helmut Klocker, Alfred Hobisch, Zoran Culig
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    Studysummary This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.
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