TLDR The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.
The document from 2012 reviews the role of the Androgen Receptor (AR) in various diseases, including cancer, and explores the potential of AR as a therapeutic target. It details AR's involvement in diseases like prostate and breast cancer, androgenetic alopecia, and polycystic ovary syndrome. The review discusses both natural and synthetic compounds that inhibit AR signaling, such as Lupeol, genistein, and the synthetic agents bicalutamide and MDV3100, the latter showing promise in early clinical trials. It also covers natural agents like quercetin and curcumin, which modulate AR activity and could serve as therapeutic agents. The document emphasizes the need for further studies to confirm the efficacy of these agents as AR antagonists and to determine appropriate dosages and treatment durations. The authors note the non-toxic nature of many natural compounds and the importance of considering interspecies differences when extrapolating results from animal studies to humans.
124 citations,
July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
402 citations,
August 2011 in “Cancer research” Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
59 citations,
May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
16 citations,
September 2018 in “Journal of Ethnopharmacology” Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.
24 citations,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
17 citations,
December 2015 in “BMC Complementary and Alternative Medicine” A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
8 citations,
July 2021 in “F1000Research” Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.
