Androgen Receptor in Human Health: A Potential Therapeutic Target
December 2012
in “
Current Drug Targets
”
TLDR The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.
The document from 2012 reviews the role of the Androgen Receptor (AR) in various diseases, including cancer, and explores the potential of AR as a therapeutic target. It details AR's involvement in diseases like prostate and breast cancer, androgenetic alopecia, and polycystic ovary syndrome. The review discusses both natural and synthetic compounds that inhibit AR signaling, such as Lupeol, genistein, and the synthetic agents bicalutamide and MDV3100, the latter showing promise in early clinical trials. It also covers natural agents like quercetin and curcumin, which modulate AR activity and could serve as therapeutic agents. The document emphasizes the need for further studies to confirm the efficacy of these agents as AR antagonists and to determine appropriate dosages and treatment durations. The authors note the non-toxic nature of many natural compounds and the importance of considering interspecies differences when extrapolating results from animal studies to humans.
