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GlossaryEnzalutamide (MDV3100)

blocks male hormones to treat prostate cancer

Enzalutamide, also known by the brand name Xtandi, is a medication used to treat prostate cancer. It works by blocking the action of androgens (male hormones) that can promote the growth of cancer cells. This drug is particularly used in cases where the cancer has spread to other parts of the body and is resistant to other treatments.

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research Redefining Hormone Resistance in Prostate Cancer

38 citations, December 2009 in “Therapeutic Advances in Medical Oncology”

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

research Recent Discoveries and Developments of Androgen Receptor-Based Therapy for Prostate Cancer

17 citations, January 2015 in “MedChemComm”

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

research Androgen Receptor in Human Health: A Potential Therapeutic Target

12 citations, December 2012 in “Current Drug Targets”

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

research Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

8 citations, March 2020 in “Frontiers in Cell and Developmental Biology”

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations, December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

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