Phytochemicals With Anti 5-Alpha-Reductase Activity: A Prospective For Prostate Cancer Treatment

    July 2021 in “ F1000Research ”
    Aziemah Azizi, Nuramalina H Mumin, N. Shafqat
    Studysummary This review discusses the potential of plant-derived phytochemicals as alternatives to 5-alpha-Reductase inhibitors in treating prostate cancer, highlighting possible benefits like reduced side effects, but it reports no new findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Screening of Euphorbiaceae Plant Extracts for Anti-5α-Reductase Activity Biological & Pharmaceutical Bulletin · 2018
    2. Hormonal Therapy in Female Pattern Hair Loss International Journal of Women's Dermatology · 2017
    3. Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review PubMed · 2016
    4. Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex Evidence-based Complementary and Alternative Medicine · 2015
    5. Plants as Potential Active Components in Treatment of Androgenetic Alopecia Herba Polonica · 2014
    6. Evaluation of 5α-Reductase Inhibitory Activity of Certain Herbs Useful as Antiandrogens Andrologia · 2013
    7. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    8. Potency of a Novel Saw Palmetto Ethanol Extract, SPET-085, for Inhibition of 5α-Reductase II Advances in Therapy · 2010
    9. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    10. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008
    11. The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer ˜The œJournal of urology/˜The œjournal of urology · 2008
    12. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    13. The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice Journal of dermatological science · 2003

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    8. Effective Treatment of Female Androgenic Alopecia with Dutasteride PubMed · 2005