Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

    July 2023 in “ Clinica Chimica Acta
    Yoshitaka Hobo, Jun Nishikawa, Noriko Asai-Taniguchi, Keisuke Yoneyama, Yozo Watanabe, Yoshimichi Miyashiro, Akira Fujikata
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    TLDR Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.
    The study evaluated the therapeutic effects of androgenetic alopecia (AGA) drugs, specifically finasteride and dutasteride, by measuring their concentrations and that of dihydrotestosterone (DHT) in hair samples from 1,078 male subjects. Using Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS), it was found that DHT concentration in hair decreased in a drug-concentration-dependent manner. The DHT concentration was significantly lower in the group where the drugs were detected compared to the group where they were not. This suggests that measuring finasteride, dutasteride, and DHT concentrations in hair could be a useful method to evaluate the effectiveness of AGA treatments.
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