Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

    June 2023 in “ Clinica Chimica Acta ”
    Yoshitaka Hobo, Jun Nishikawa, Noriko Asai-Taniguchi … Akira Fujikata
    Studysummary This study observed that both finasteride and dutasteride significantly decreased dihydrotestosterone concentrations in hair, with dutasteride showing the greatest reduction.
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    Research cited in this study 19

    1. Analysis of Hair Steroid Hormone Concentrations at Different Parts of the Head by Liquid Chromatography-Tandem Mass Spectrometry Clinica Chimica Acta · 2021
    2. Measurement of Steroid Hormones by Liquid Chromatography-Tandem Mass Spectrometry with Small Amounts of Hair Steroids · 2020
    3. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    4. Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia Journal of Dermatology · 2016
    5. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia Annals of Dermatology · 2016
    6. Simultaneous Pharmacokinetic and Pharmacodynamic Analysis of 5α-Reductase Inhibitors and Androgens by Liquid Chromatography Tandem Mass Spectrometry Talanta · 2014
    7. Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia Australasian Journal of Dermatology · 2012
    8. Finasteride, 1 Mg Daily Administration on Male Androgenetic Alopecia in Different Age Groups: 10-Year Follow-Up Dermatologic Therapy · 2011
    9. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    10. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    11. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    12. Journal Review: Long-Term (5-Year) Multinational Experience with Finasteride 1mg in the Treatment of Men with Androgenetic Alopecia Hair transplant forum international · 2002
    13. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    14. Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations Analytical Chemistry · 1998
    15. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    16. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994
    17. Androgens and Human Hair Growth Clinical endocrinology · 1994
    18. Finasteride: The First 5α-Reductase Inhibitor Pharmacotherapy · 1993
    19. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990

    Related research 4

    1. Luncheon Symposium: Update on the Efficacy and Safety of Dutasteride in the Management of Androgenetic Alopecia 프로그램북(구 초록집) · 2015
    2. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    3. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    4. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994