Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

May 2004 in “ The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism ”

Richard V. Clark, David Hermann, Glenn R. Cunningham, Timothy H. Wilson, Betsy Morrill, S. F. Hobbs

dutasteride 5α-reductase inhibitor dihydrotestosterone DHT benign prostatic hyperplasia BPH finasteride Avodart Propecia

TLDR Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

The study demonstrated that dutasteride, a dual 5α-reductase inhibitor, significantly suppressed dihydrotestosterone (DHT) levels in men with benign prostatic hyperplasia (BPH) over 24 weeks. Higher doses of dutasteride (2.5 mg and 5.0 mg) resulted in greater DHT suppression (97.7% and 98.4%, respectively) compared to finasteride (70.8%). The study included 399 participants and concluded that dutasteride was more effective in lowering DHT levels and managing BPH symptoms, with a safety profile similar to placebo.

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Research cited in this study

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Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

Research cited in this study

research The Long-Term Effect of Specific Type II 5alpha-Reductase Inhibition with Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo Controlled Trial

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research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

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