Comparison of Clinical Efficacy of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors

    January 2012 in “ Daehan namseong gwahag hoeji ”
    Hoon Choi, Young Woon Chang, Byung-Hun Park, Dong-Hoon Ko, Young Hoon Moon, Jin-Soo Kim
    From the encyclopedia
    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Dutasteride →

    Heavy duty finasteride that comes with higher risks

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    Studysummary This study found that dutasteride was more effective than finasteride in reducing total prostate volume and PSA levels and improving symptoms in patients with benign prostate hyperplasia.
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    The 2012 study involving 354 patients with Benign Prostatic Hyperplasia (BPH) compared the efficacy of finasteride and dutasteride, both 5-alpha reductase inhibitors. The results showed that dutasteride was more effective in reducing total prostate volume (TPV) by 28.2% and Prostate-Specific Antigen (PSA) levels by 43.6%, compared to finasteride's reduction of TPV by 20.5% and PSA by 39.2%. However, both drugs had similar side effects and there were no significant differences in quality of life score, maximal flow rate increment, or post-void residual urine reduction. The study concluded that more large-scale studies were needed to definitively compare the two drugs.
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