Comparison of Clinical Efficacy of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors
April 2012
in “
Daehan namseong gwahag hoeji
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TLDR Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.
The 2012 study involving 354 patients with Benign Prostatic Hyperplasia (BPH) compared the efficacy of finasteride and dutasteride, both 5-alpha reductase inhibitors. The results showed that dutasteride was more effective in reducing total prostate volume (TPV) by 28.2% and Prostate-Specific Antigen (PSA) levels by 43.6%, compared to finasteride's reduction of TPV by 20.5% and PSA by 39.2%. However, both drugs had similar side effects and there were no significant differences in quality of life score, maximal flow rate increment, or post-void residual urine reduction. The study concluded that more large-scale studies were needed to definitively compare the two drugs.
