Effect of Finasteride and/or Terazosin on Serum PSA: Results of VA Cooperative Study #359

    June 1999 in “ The Prostate ”
    Michael K. Brawer, Daniel W. Lin, William O. Williford, Michael Horowitz, Herbert Lepor
    Image of study
    TLDR Finasteride reduces PSA levels, terazosin doesn't affect them, and tracking prostate cancer in patients taking finasteride could be difficult.
    The study investigated the effect of finasteride and/or terazosin on serum prostate-specific antigen (PSA) levels in men with benign prostatic hyperplasia (BPH). The study included patients enrolled in the VA Cooperative Study #359 trial and evaluated four treatment groups: placebo, finasteride, terazosin, and a combination of finasteride plus terazosin. The results showed that there was no significant difference in baseline PSA levels between the four groups. However, at 52 weeks, there was a statistically significant reduction in PSA levels in the finasteride and combination therapy groups, while significant increases were observed in the terazosin and placebo groups. The study concluded that terazosin had no clinically significant effect on PSA levels, and the heterogeneity of PSA response to finasteride may make monitoring patients for the development of prostate cancer problematic.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Topical fin formulation question

      in Finasteride  75 upvotes 1 week ago
      A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

      community Topical finasteride carrier/vehicle

      in Finasteride  135 upvotes 3 weeks ago
      The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

      community Chest discomfort on finasteride?

      in Finasteride  72 upvotes 3 months ago
      A user experienced chest discomfort after taking finasteride for hair loss and is concerned about whether it is a side effect or an allergy. They are advised to consult a doctor and consider other hair loss treatments if necessary.
      M27 Fin/Min (topical) was fun while it lasted

      community M27 Fin/Min (topical) was fun while it lasted

      in Finasteride  126 upvotes 3 months ago
      The user experienced significant hair regrowth using topical Minoxidil and Finasteride but had to stop due to high liver enzyme levels. They plan to pause treatment for a month to see if their liver values return to normal.

      community Getting Ed from 1mg of fin not sure what to do

      in Finasteride  190 upvotes 4 months ago
      The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

      community Topical finasteride in liposomal formulation

      in Finasteride  5 upvotes 4 years ago
      Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

    Similar Research

    5 / 1000+ results