Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia

June 2012 in “ Australasian Journal of Dermatology ”

Ann Boyapati, Rodney Sinclair

finasteride dutasteride androgenetic alopecia hair density hair growth hair loss Propecia Avodart

TLDR Finasteride and low-dose dutasteride combo improves hair growth and reduces hair loss with no major side effects.

The paper reports on a case study of a man with androgenetic alopecia who was treated with a combination of finasteride and low-dose dutasteride, resulting in a significant increase in hair density. The study also investigated the effectiveness of the combination therapy in 37 men with androgenetic alopecia, showing that it was effective in improving hair growth and reducing hair loss with no significant side effects. The study suggests that combination therapy with finasteride and low-dose dutasteride may be a promising treatment option for androgenetic alopecia.

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Research cited in this study

7 / 7 results

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations, November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

100 citations, September 1999 in “British Journal of Dermatology”

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

research Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss

187 citations, June 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively treats frontal hair loss with few side effects.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations, October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations, September 1998 in “BMJ”

Hair loss in men is common, treatable, but not curable.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community The no BS guide to saving your hair without finasteride (improvement in 90% of patients in the study) with a low side effect profile or improvement in 100% of patients but a higher side effect profile and increased dosage. The future is here?

in Minoxidil 92 upvotes 4 years ago

Hair loss treatments, specifically the use of oral minoxidil in combination with micro-needling. Oral minoxidil has been found to improve hair density in 90% of patients with a low side effect profile, but using 5mg per day can result in higher side effects including hypertrichosis and edema. Other treatments mentioned include finasteride and RU58841.

community 1mg fin daily. 1 month, 11 months, 1 year 2 months.

in Finasteride/Dutasteride 2123 upvotes 5 months ago

A user shared impressive hair regrowth results after using 1mg finasteride daily for over a year, with minimal side effects. The user also mentioned taking biotin gummies and experiencing periods of shedding followed by thicker hair growth.

community Finasteride and Dutasteride results compilation thread

in Finasteride/Dutasteride 82 upvotes 3 weeks ago

Combining finasteride and dutasteride may enhance hair regrowth by targeting different enzymes, with positive results reported. Minoxidil, both oral and topical, is also used to improve effectiveness.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

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The review found that women using hair loss drugs like finasteride and dutasteride rarely reported sexual side effects.

research Is There a Relationship Between Androgenic Alopecia and Benign Prostatic Hyperplasia?

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There's no link between hair loss type androgenic alopecia and benign prostatic hyperplasia, but early hair loss and family history can mean more severe alopecia.