The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice

April 2013 in “ The FASEB Journal ”

Alexander B. Opoku‐Acheampong, Dave Unis, Amanda P. Beck, Jamie Henningson, Brian Lindshield

finasteride dutasteride 5α-reductase inhibitors 5αR1 5αR2 prostate cancer TRAMP mice genitourinary tract prostatic intraepithelial neoplasia PIN Propecia Avodart

TLDR Dutasteride showed some prevention of prostate issues but also had limitations, especially with high-grade tumors.

The study investigated the preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice, focusing on prostate cancer development. Finasteride, which inhibits only 5αR2, was hypothesized to be less effective than dutasteride, which inhibits both 5αR1 and 5αR2. Mice were divided into control and drug diet groups, with treatments starting at 6 and 12 weeks of age and ending at 20 weeks. The study found that pre-dutasteride treatment reduced final body weights and genitourinary tract weights, while both pre- and post-dutasteride treatments decreased high-grade prostatic intraepithelial neoplasia (PIN) incidence. However, there was an increased incidence of poorly differentiated cancer in the dorsal lobe for pre-dutasteride and both finasteride groups. These findings showed some similarities with previous clinical trial results.

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community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 2 years ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 11 upvotes 1 year ago

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community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 66 upvotes 1 year ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community No fearmongering /just facts on yesterday someone posting on eye issues

in Finasteride/Dutasteride 33 upvotes 7 months ago

Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.

community Dutasteride thins eyebrows and facial hair but doesn't stop scalp loss.

in Finasteride/Dutasteride 37 upvotes 5 months ago

Dutasteride may not effectively stop scalp hair loss and can cause thinning of facial and body hair, including eyebrows. Users suggest considering other causes like autoimmune conditions or vitamin deficiencies and exploring treatments like finasteride or minoxidil.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 157 upvotes 1 year ago

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