The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

    February 2007 in “ The Journal of Clinical Endocrinology and Metabolism ”
    John K. Amory, Christina Wang, Ronald S. Swerdloff, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, Susan P. Walker, Lynda J. Haberer, Richard F. Clark
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    TLDR Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
    A study from 16 years ago found that dutasteride and finasteride, two drugs used for hair loss treatment, can decrease semen volume, sperm concentration, and total sperm count in healthy men, but do not affect sperm motility or morphology. The drugs also lower serum levels of DHT and PSA, but the changes in semen parameters are reversible after stopping the drugs. The study suggests that these drugs should be used with caution in men who desire fertility.
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      in Satire  7 upvotes 5 months ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

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      in Research  330 upvotes 7 months ago
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      in Finasteride/Dutasteride  72 upvotes 4 years ago
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