Prolonged Treatment with Finasteride (a 5α-Reductase Inhibitor) Does Not Affect Bone Density and Metabolism

November 1992 in “ Clinical Endocrinology ”

Halm Matzkin, Juza Chen, Yosef Weisman, David Goldray, Fran Pappas, Niva Jaccard, Zvl Braf

finasteride 5α-reductase inhibitor 1,25(OH)₂D3 Propecia

TLDR Long-term finasteride use doesn't change bone density or metabolism.

The study aimed to evaluate the effect of finasteride, a 5α-reductase inhibitor, on bone density and metabolism in elderly men. The results showed that prolonged treatment with finasteride did not affect bone density or mineral metabolism, except for a small increase in 1,25(OH)₂D3 serum concentration. The study suggests that finasteride is a safe drug as pertains to bone and mineral metabolism.

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Research cited in this study

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research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations, November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

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Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

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in Research/Science 111 upvotes 8 months ago

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.