Prolonged Treatment with Finasteride (a 5α-Reductase Inhibitor) Does Not Affect Bone Density and Metabolism

    November 1992 in “ Clinical Endocrinology ”
    Halm Matzkin, Juza Chen, Yosef Weisman, David Goldray, Fran Pappas, Niva Jaccard, Zvl Braf
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    TLDR Long-term finasteride use doesn't change bone density or metabolism.
    The study aimed to evaluate the effect of finasteride, a 5α-reductase inhibitor, on bone density and metabolism in elderly men. The results showed that prolonged treatment with finasteride did not affect bone density or mineral metabolism, except for a small increase in 1,25(OH)₂D3 serum concentration. The study suggests that finasteride is a safe drug as pertains to bone and mineral metabolism.
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