Prolonged Treatment with Finasteride (a 5α-Reductase Inhibitor) Does Not Affect Bone Density and Metabolism

November 1992 in “ Clinical Endocrinology ”

Halm Matzkin, Juza Chen, Yosef Weisman, David Goldray, Fran Pappas, Niva Jaccard, Zvl Braf

finasteride 5α-reductase inhibitor 1,25(OH)₂D3 Propecia

TLDR Long-term finasteride use doesn't change bone density or metabolism.

The study aimed to evaluate the effect of finasteride, a 5α-reductase inhibitor, on bone density and metabolism in elderly men. The results showed that prolonged treatment with finasteride did not affect bone density or mineral metabolism, except for a small increase in 1,25(OH)₂D3 serum concentration. The study suggests that finasteride is a safe drug as pertains to bone and mineral metabolism.

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Research cited in this study

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research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations, November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

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Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

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in Research/Science 111 upvotes 9 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.