The Long-Term Effect of Specific Type II 5α-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo-Controlled Trial

    May 2002 in “ The Journal of Urology ”
    ALVIN M. MATSUMOTO, LISA TENOVER, MICHAEL McCLUNG, DAVID MOBLEY, JACK GELLER, MICHAEL SULLIVAN, JOHN GRAYHACK, HUNTER WESSELLS, DOV KADMON, MALACHI FLANAGAN, GANG K. ZHANG, JOSEPH SCHMIDT, ALICE M. TAYLOR, MICHAEL LEE, JOANNE WALDSTREICHER
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    TLDR Finasteride doesn't harm bone density in older men with BPH.
    This study examined the long-term effects of finasteride, a type II 5α-reductase inhibitor, on bone mineral density in men with benign prostatic hyperplasia. The study involved 157 patients who were randomized to receive either finasteride or a placebo for four years. The results showed that long-term inhibition of type II 5α-reductase with finasteride did not adversely affect bone mineral density. The study concluded that long-term inhibition of type II 5α-reductase with reduced dihydrotestosterone does not adversely affect bone mineral density in older men with BPH.
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