Screening of Euphorbiaceae Plant Extracts for Anti-5α-Reductase Activity

July 2018 in “ Biological & Pharmaceutical Bulletin ”

Hiroyasu Kamei, Kazuma Noguchi, Hideaki Matsuda, Kazuya Murata

5α-reductase androgenetic alopecia Phyllanthus urinaria stigmasterol glucoside androgen activity LNCaP cell line hair regrowth alopecia 5-alpha-reductase male pattern baldness P. urinaria hair loss

TLDR Phyllanthus urinaria extract may help treat hair loss by blocking a hair-related enzyme.

In a study by Hiroaki Kamei and colleagues from 2018, extracts from the Euphorbiaceae family were tested for their ability to inhibit 5α-reductase, an enzyme linked to androgenetic alopecia. The extract from Phyllanthus urinaria showed the highest inhibition, with 24.3% at 50 µg/mL and 64.6% at 200 µg/mL. Additionally, this extract reduced androgen activity in the LNCaP cell line and promoted hair regrowth in a mouse model at a dose of 5 mg/mouse/day. The compound stigmasterol glucoside was identified as the active anti-5α-reductase agent, with an IC50 of 27.2 μM. These results suggest that P. urinaria extract and stigmasterol glucoside could be effective for treating alopecia.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract

49 citations , April 2012 in “Phytotherapy Research”

Rosemary leaf extract may be an effective natural treatment for hair growth and male pattern baldness.

research Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities

34 citations , August 2011 in “Journal of Natural Medicines”

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Regrowth in Testosterone-Treated Mice

51 citations , May 2011 in “Phytotherapy Research”

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

Related Community Posts Join

6 / 180 results

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 1 year ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 25 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Does ketokonazole on its own improve androgenetic alopecia?

in Ketoconazole 10 upvotes 1 week ago

Ketoconazole can slightly improve hair density and is best used as an adjunct to treatments like finasteride and minoxidil. It helps with scalp health but won't stop androgenetic alopecia on its own.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 4 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 5 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

in Research/Science 28 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

Related Research

4 / 4 results

Screening of Euphorbiaceae Plant Extracts for Anti-5α-Reductase Activity