Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract

    April 2012 in “ Phytotherapy Research ”
    Kazuya Murata, Kazuma Noguchi, Masato Kondo, Mariko Onishi, Nozomi Watanabe, Katsumasa Okamura, Hideaki Matsuda
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    Studysummary This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.
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    The study from 2012 investigated the effects of Rosmarinus officinalis leaf extract (RO-ext) on hair growth, particularly as a potential treatment for androgenic alopecia. The extract was topically applied to mice at a dosage of 2 mg/day/mouse, leading to improved hair regrowth in testosterone-treated C57BL/6NCrSlc mice and in shaved C3H/He mice. RO-ext showed significant inhibition of testosterone 5α-reductase, with up to 94.6% inhibition at 500 µg/mL, and the active component responsible was identified as 12-methoxycarnosic acid. Additionally, RO-ext and 12-methoxycarnosic acid inhibited androgen-dependent cell proliferation, suggesting they may block dihydrotestosterone from binding to androgen receptors. The study, which used groups of 10 mice for hair regrowth tests, concluded that RO-ext, especially due to 12-methoxycarnosic acid, could be a promising natural treatment for hair growth and androgenetic alopecia.
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