Biochemical Analysis of Hair Growth from the Aspects of Aging and Enzyme Activities

The study investigated hair regrowth in C3H mice of varying ages by examining enzyme activities in different skin areas after shaving. It was found that hair regrowth was irregular and delayed as the mice aged, with older mice showing more significant delays. Biochemical analysis of 18 mice revealed that enzyme activities, specifically ornithine decarboxylase (ODC), transglutaminase (TGase), and alkaline phosphatase (Al-P), were significantly higher in areas where hair was regrowing compared to non-growing areas. This suggested that these enzymes played a role in hair regrowth, with increased activity in follicle-rich regions.