Formation of the Iε-(γ-Glutamyl)Lysine Crosslink in Hair Proteins: Investigation of Transamidases in Hair Follicles

    July 1972 in “ Biochemistry ”
    Harry W.J. Harding, George E. Rogers
    TLDR Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.
    The 1972 study investigated the formation of iε-(γ-glutamyl)lysine crosslinks in hair proteins and the role of transamidases in hair follicles, focusing on the enzymatic processes crucial for hair's structural integrity. The research provided insights into the biochemical mechanisms of hair protein crosslinking, contributing to the understanding of hair biology and potential implications for hair growth and hair loss treatments.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community I cant believe its actually working…

      in Finasteride/Dutasteride  23 upvotes 5 days ago
      The user experienced significant hair regrowth using 1mg oral finasteride, DIM, and beetroot powder, while also focusing on gut health and reducing alcohol intake. Other users discussed the importance of iodine, fermented foods, and maintaining a balanced diet for overall health and hair improvement.

      community I think waiting it out and adding oral minox did the trick!

      in Update  8 upvotes 1 week ago
      A 23-year-old male experienced hair regrowth by adding oral minoxidil to his regimen, which already included dutasteride, topical minoxidil, ketoconazole shampoo, and levothyroxine. He also uses microneedling, biotin vitamins, and exercises regularly, reporting no side effects from oral minoxidil so far.

    Similar Research

    5 / 1000+ results

      research Proteome Analysis of Human Hair Shaft

      122 citations , January 2006 in “Molecular & Cellular Proteomics”
      Human hair contains many proteins, with some being highly abundant and modified.

      research Vertebral Epidermal Transamidases

      49 citations , May 1974 in “Biochimica et Biophysica Acta (BBA) - Protein Structure”
      Transamidases are present in the epidermis but their exact role is unclear.

      research The Fate of Trichohyalin

      135 citations , October 1997 in “Journal of biological chemistry/˜The œJournal of biological chemistry”
      Trichohyalin is modified by enzymes to form strong structures in hair cells.

      research Cell Death by Cornification

      375 citations , June 2013 in “Biochimica et biophysica acta. Molecular cell research”
      Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.