4 citations
,
June 2022 in “Journal of cleaner production”
This study found that a new eco-friendly haircrosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.
This study investigated the formation of a specific chemical crosslink in hairproteins and explored the role of transamidase enzymes in hair follicles.
6 citations
,
April 2005 in “Journal of dermatological science”
This study identified the expression sites of five KAP5 genes on human chromosome 11q13.5 in scalp skin sections but did not explore their detailed distribution within hair follicles.
Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).
Whey protein does not cause hair loss; concerns are likely unfounded. The user is on finasteride and minoxidil but sees no improvement, so they are phasing out these treatments while continuing to work out and use whey protein.
The user started using ketoconazole shampoo and whey protein shakes and noticed increased hair shedding, seeking advice on whether these could be the cause. Another user shared their experience with hair loss after starting protein shakes and mentioned using finasteride, which eventually improved their hair condition.
A 37-year-old with a receding hairline started using finasteride and plans to add minoxidil, concerned that creatine and whey protein might accelerate hair loss. Another user suggests these supplements likely don't increase testosterone or cause hair loss, advising to monitor personal experience.
Protein's role in hair growth is complex, with specific amino acids like cysteine being crucial for effective hair growth. Users discussed using l-cysteine supplements, noting reduced hair loss and faster growth, though some experienced digestive issues.
How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride?Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.
Protein that blocks activin, a growth-regulating signal
What is follistatin, and how does it influence hair follicle growth and regeneration?Follistatin blocks activin and related growth-inhibiting proteins, which mouse studies link to hair follicle development and cycling; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.