TLDR The study found nine new hair protein genes in human hair follicles.
The study focused on the expression of novel keratin-associated protein 5 (KAP5) genes in the cuticle layer of human hair follicles. Hair keratin proteins and KAPs are crucial structural components of hair fibers, with KAPs functioning as disulfide bond cross-linking proteins. While previous research identified two KAP5 genes on human chromosome 11, this study mapped nine additional KAP5 members on chromosomes 11p15.5 and 11q13.5. Using RT-PCR, the expression of all KAP5 genes in hair roots was confirmed, but their detailed distribution within hair follicles was not previously explored. This study compared the expression sites of five KAP5 genes on chromosome 11q13.5 using scalp skin sections, providing new insights into their specific localization in hair follicles.
62 citations,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.
67 citations,
December 1990 in “The journal of cell biology/The Journal of cell biology” Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.
98 citations,
May 2016 in “Genes” Understanding wool keratin-associated proteins in sheep can help improve wool quality through selective breeding.
51 citations,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
6 citations,
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48 citations,
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100 citations,
December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
