Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

    February 2002 in “ Current Opinion in Cell Biology ”
    Pierre A. Coulombe, M. Bishr Omary
    TLDR Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.
    This review explored the structure, function, and regulation of keratin intermediate filaments (IFs), highlighting both established ('hard') and emerging ('soft') principles. It discussed the discovery of novel keratin genes, the mechanics of keratin filaments, and the functional redundancy revealed by gene knockouts. The study also examined the role of keratin mutations in various diseases and the regulation of keratin through interactions with other proteins. The field was noted to be rapidly advancing, driven by transgenic models and new insights into keratin's protective roles in cellular stress responses.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 191 results

      community 28m - Last 26 days have been great

      in Progress Pictures  14 upvotes 3 months ago
      A 28-year-old male shares his hair regrowth progress using finasteride, topical and oral minoxidil, hair peptide serum, ketoconazole shampoo, dermastamping, multivitamins, and a high-protein diet. He reports noticeable hair growth and minor side effects, emphasizing patience as key to success.

      community Can toppik fibers cause hair loss?

      in Chat  1 upvotes 2 years ago
      Toppik fibers causing hair loss is questioned. Applying it may pull out already shed hairs, and user experiences oral minoxidil shedding.

      community Hair progress from a year ago to today

      in Progress Pictures  128 upvotes 2 years ago
      A user shared their daily hair loss treatment routine, which includes 1mg of oral finasteride, 1mg of oral minoxidil, 1ml of castor oil, biotin, collagen, multivitamins, zinc, magnesium, liver supplements, RU58841 every night, and ketoconazole shampoo twice a week. They also mentioned a healthy lifestyle and a past unsuccessful hair transplant, but have experienced hair regrowth and thickening since starting their current regimen.

    Similar Research

    5 / 1000+ results