Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia

    May 2001 in “ Development ”
    Andrei V. Tkatchenko, Richard P. Visconti, Lijuan L. Shang … Alexander Awgulewitsch
    Studysummary This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.
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    Research cited in this study 10

    1. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
    2. Pmg-1 and Pmg-2 Constitute a Novel Family of KAP Genes Differentially Expressed During Skin and Mammary Gland Development Mechanisms of Development · 1999
    3. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    4. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998
    5. Isolation and Characterization of Mouse High-Glycine/Tyrosine Proteins Journal of Biological Chemistry · 1997
    6. The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair Birkhäuser Basel eBooks · 1997
    7. Isolation and Characterization of a Novel Hair Follicle-Specific Gene, Hacl-1 Journal of Investigative Dermatology · 1994
    8. Regulation of Keratin Gene Expression in Hair Follicle Differentiation Annals of the New York Academy of Sciences · 1991
    9. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    10. Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA Journal of Investigative Dermatology · 1988