Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

January 2023 in “ Kafkas üniversitesi veteriner fakültesi dergisi/Kafkas üniversitesi veteriner fakültesi dergisi ”

Bengi ÇINAR KUL, Nüket Bilgen, Merve BİŞKİN, Mustafa Yenal Akkurt, Özge Şebnem Çıldır, Özge ÖZMEN, Oğuz Kul

hair follicle development gene expression telogen anagen BMP-2 FGF-5 HOXC13 KAP9.2 TGFBR2 overexpression non-medullary hair structure hair growth phases bone morphogenetic protein 2 fibroblast growth factor 5 homeobox C13 keratin-associated protein 9.2 transforming growth factor beta receptor 2

TLDR Seasonal changes affect gene activity linked to hair growth in Angora goats.

The study investigated the impact of seasonal changes on the gene expression related to hair follicle development in Angora goats, focusing on the mohair produced by these animals. Skin biopsies from 20 goats were analyzed at two different stages of follicle development: telogen in February and anagen in June. The genes BMP-2, FGF-5, HOXC13, KAP9.2, and TGFBR2 were examined, with HOXC13 showing significant overexpression during the anagen phase (P<0.005) and undetectable levels during telogen. BMP-2, FGF-5, and TGFBR2 were also significantly upregulated in the anagen phase (P<0.005 for BMP-2 and FGF-5; P<0.01 for TGFBR2), while KAP9.2 did not show a significant difference between the two phases. This study is the first to explore hair follicle-related genes in Angora goats and suggests that the overexpression of HOXC13 may be a key factor in the development of their non-medullary hair structure.

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