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    Glossary Overexpression

    production of a gene's product in unusually high amounts

    Overexpression refers to the process where a gene is produced in higher-than-normal amounts within a cell. This can happen naturally or be induced artificially in a lab setting. In the context of hair and alopecia, overexpression of certain genes might lead to excessive hair growth or, conversely, contribute to hair loss if the overexpressed gene disrupts normal hair follicle function.

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    1. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings of the National Academy of Sciences · 1994 · 211 citations
    2. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair EMBO journal · 1999 · 204 citations
    3. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    4. Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion Journal of Cell Science · 1999 · 135 citations
    5. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    6. Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues The EMBO Journal · 2002 · 111 citations
    7. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    8. Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice American Journal Of Pathology · 2008 · 55 citations
    9. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis Developmental Biology · 2003 · 53 citations
    10. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000 · 47 citations
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