Targeted Overexpression of Parathyroid Hormone-Related Peptide in Chondrocytes Causes Chondrodysplasia and Delayed Endochondral Bone Formation

    September 1996 in “ Proceedings of the National Academy of Sciences ”
    Eleanor C. Weir, William M. Philbrick, Michael Amling … A E Broadus
    Studysummary This study found that overexpression of PTHrP in mice chondrocytes led to short-limbed dwarfism and delays in endochondral ossification, highlighting PTHrP's role in inhibiting chondrocyte differentiation.
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    Research cited in this study 1

    1. Overexpression of Parathyroid Hormone-Related Protein in the Skin of Transgenic Mice Interferes with Hair Follicle Development Proceedings of the National Academy of Sciences · 1994

    Related research 1

    1. Targeted Overexpression of Parathyroid Hormone-Related Peptide in Chondrocytes Causes Chondrodysplasia and Delayed Endochondral Bone Formation Proceedings of the National Academy of Sciences · 1996