FGF5 Is a Crucial Regulator of Hair Length in Humans

July 2014 in “ Proceedings of the National Academy of Sciences of the United States of America ”

Claire A. Higgins, Lynn Petukhova, Sivan Harel, Yuan Y. Ho, Esther Drill, Lawrence Shapiro, Muhammad Wajid, Angela M. Christiano

FGF5 fibroblast growth factor 5 trichomegaly anagen catagen hair follicles hair growth hair elongation hair growth phase hair growth inhibition

Studysummary This study identified mutations in the FGF5 gene as a cause of extreme eyelash growth in Pakistani families, highlighting a potential target for regulating eyelash growth.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on pnas.org →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias

53 citations , October 2012 in “The FASEB Journal”

This study found that bimatoprost stimulated hair growth in both human scalp follicle cultures and mouse pelage in vivo, suggesting it might offer a promising treatment for scalp alopecias.

research Eyelash Trichomegaly: Review of Congenital, Acquired, and Drug-Associated Etiologies for Elongation of the Eyelashes

24 citations , May 2012 in “International Journal of Dermatology”

This review discusses the various causes and associations of eyelash trichomegaly, including congenital syndromes, acquired conditions, and drug effects, without reporting new clinical results.

research Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

75 citations , September 2007 in “Journal of Heredity”

This study found that mutations in the FGF5 gene are the primary genetic factor causing long hair in domestic cats through an autosomal recessive mechanism.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.

research Short Anagen Syndrome

37 citations , July 2005 in “Journal of The American Academy of Dermatology”

This article reviews the clinicopathologic features of short anagen syndrome in a child and suggests diagnostic methods like clinical examination and scalp hair growth rate measurement, without reporting new clinical results.

research Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle

37 citations , July 1999 in “The EMBO Journal”

Overexpression of certain genes can shorten hair by disrupting the hair-growth cycle.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research The Hair Cycle on the Human Thigh and Upper Arm

67 citations , July 1985 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that males have significantly longer hair on their thighs compared to females, mainly due to a longer anagen phase and a greater rate of growth.

research Minoxidil and the Treatment of Severe Hypertension

51 citations , October 1980 in “The New England Journal of Medicine”

Minoxidil lowers blood pressure effectively but may cause unwanted hair growth and other side effects.

research Endocrine Influences on Hair Growth

68 citations , March 1965 in “The BMJ”

Hormones and genetics affect hair growth and patterns, with some changes reversible and others not.