Blockade of S100A3 Activity Inhibits Murine Hair Growth

January 2015 in “ Genetics and Molecular Research ”

Wen Guan, Qing Deng, Xiaopeng Yu, Yunsheng Yuan, Jin Gao, Jinjin Li, Libin Zhou, Peng Xia, Gangwen Han, Han Wang, Yan Yu

S100A3 anti-S100A3 antibody hair follicles hair growth induction hair regeneration

Studysummary This study demonstrated that blocking S100A3 in mice inhibited hair growth by delaying the anagen phase and reducing the number of hair follicles, suggesting S100A3 as a potential target for hair loss treatments. Our plain-language summary of this paper — not a Tressless recommendation.

In the 2015 study by Guan et al., the role of S100A3 in hair growth was examined using a mouse model. The researchers found that blocking S100A3 activity with an anti-S100A3 antibody led to delayed hair growth, shorter hair shafts, and fewer hair follicles. This was accompanied by lower expression of genes associated with hair growth induction. The study, which involved 20 mice divided into two groups of 10, concluded that S100A3 is important for hair regeneration and could be a potential target for hair loss treatments.

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