TLDR S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
The study examines the expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with hair follicle regeneration. The study found that S100A4 and S100A6 proteins are present in specific areas of the epithelial sac related to hair follicle regeneration and may play a role in activating stem cells during hair follicle regeneration. The study provides insights into the mechanisms of hair follicle regeneration and suggests that S100A4 and S100A6 proteins could be potential targets for hair loss treatments.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
40 citations,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” S100A3 protein is crucial for hair shaft formation in mice.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
236 citations,
January 1951 in “Physiological zoology” Hair growth and pigmentation in mice involve specific stages crucial for research.
36 citations,
October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
45 citations,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
520 citations,
February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
