research S100A6: Molecular Function and Biomarker Role
S100A6, a Ca2+-binding protein from the S100 family, plays crucial roles in cytoskeleton dynamics, cell stress response, proliferation, and differentiation. It interacts with various proteins in a Ca2+-dependent manner, influenced by specific binding motifs. The expression of S100A6 is regulated by transcription factors like c-Myc and P53, and is affected by epigenetic modifications such as histone acetylation and DNA methylation. Its differential expression across diseases and stages makes S100A6 a valuable biomarker for diagnosis and prognosis, as well as a potential therapeutic target. This review highlights S100A6's ligand interactions, transcriptional regulation, molecular functions, and its significance in human diseases and stem cells.
