S100A6: Molecular Function and Biomarker Role

S100A6, a calcium-binding protein from the S100 family, is involved in various cellular processes such as cytoskeleton dynamics, stress response, proliferation, and differentiation. It interacts with proteins in a Ca2+-dependent manner and is regulated by transcription factors like c-Myc and P53. S100A6 is differentially expressed in several cancers, making it a valuable biomarker for diagnosis and prognosis, and a potential therapeutic target. It is also expressed in various stem cells, highlighting its role in stem cell identification and regenerative medicine. Further large-scale studies are needed to validate its prognostic value in cancers.