A Symphony of Signals: The Intricate Role of lncRNAs in Dermatological Disorders

November 2025 in “ Clinical and Experimental Medicine ”

Ahmad Ghorbani Vanan, Samaneh Nouri, Fatemeh Ghasabeh Hassanzadeh, Milad Taghizadeh-Anvar, Mehdi Heidari Naeij, Aida Varghaei, Safa Tahmasebi

long non-coding RNAs lncRNAs PI3K/AKT/mTOR Wnt/β-catenin skin homeostasis atopic dermatitis psoriasis melanoma biomarkers therapeutic targets

TLDR lncRNAs are important for understanding and treating skin diseases.

Recent genomic research has revealed that long non-coding RNAs (lncRNAs) are crucial regulators of gene expression, influencing key signaling pathways such as PI3K/AKT/mTOR and Wnt/β-catenin, which are vital for skin homeostasis and disease processes. This review highlights the role of lncRNAs in dermatological disorders like atopic dermatitis, psoriasis, and melanoma, suggesting their potential as biomarkers and therapeutic targets. The study emphasizes the clinical relevance of lncRNA research in understanding and treating skin diseases.

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