The Molecular Revolution in Cutaneous Biology: Noncoding RNAs as New Molecular Players in Dermatology and Cutaneous Biology

    April 2017 in “ Journal of Investigative Dermatology ”
    Natalia V. Botchkareva
    TLDR Non-coding RNAs are crucial for skin development and health.
    The document discussed the significant roles of non-coding RNAs, particularly miRNAs and lncRNAs, in regulating skin development and homeostasis. It highlighted that only about 2% of the genome codes for proteins, while a large portion encodes non-coding RNAs, which are crucial for genome stability and activity. Research showed that miRNAs are essential for normal skin and hair follicle development, with specific miRNAs like miR-203 playing a key role in promoting epidermal differentiation by targeting genes involved in cell cycle regulation. The findings underscored the importance of non-coding RNAs in both normal skin function and various skin disorders.
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