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Glossary Long Non-Coding RNAs

regulate gene expression without coding for proteins

Long Non-Coding RNAs (lncRNAs) are a type of RNA molecule that are longer than 200 nucleotides and do not code for proteins. Instead, they play crucial roles in regulating gene expression, influencing processes such as cell differentiation, development, and disease mechanisms, including those related to hair growth and alopecia.

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Research

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research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

This study identified key long non-coding RNAs and mRNAs involved in primary wool follicle induction in carpet wool sheep, emphasizing their roles in hair follicle development and skin processes.

Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

research Melatonin promotes Cashmere goat (Capra hircus) secondary hair follicle growth: a view from integrated analysis of long non-coding and coding RNAs

32 citations , May 2018 in “Cell Cycle”

This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.

research Genomewide differential expression profiling of long non-coding RNAs in androgenetic alopecia in a Chinese male population

11 citations , April 2017 in “Journal of The European Academy of Dermatology and Venereology”

This study found that long non-coding RNAs are differentially expressed in androgenetic alopecia, suggesting potential roles in its development and novel targets for prevention and treatment.

research Melatonin promotes Cashmere goat (Capra hircus) secondary hair follicle growth: a view from integrated analysis of long non-coding and coding RNAs

January 2021 in “Figshare”

This study reported that exposure to melatonin promoted hair follicle fiber growth in an in vitro Cashmere goat model, potentially by influencing pathways related to the extracellular matrix and microvascular system.

research 139 Identification of long noncoding RNAs in mouse hair follicle stem cells using computational methods

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study investigated the roles of long non-coding RNAs in mouse hair follicle stem cells, using sequencing to identify potential biomarkers and targets for treatments in both mice and humans.

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Community Join

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community Journey against alopecia - Finasteride 3 month

17 upvotes 4 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community 15yo with severe anxiety from Norwood 2.5 and thinning

in Finasteride/Dutasteride 15 upvotes 1 year ago

A 15-year-old experiencing hair loss and anxiety is using minoxidil and microneedling but is advised against starting finasteride or dutasteride due to age. The discussion emphasizes consulting a doctor, considering hormonal evaluations, and exploring non-medication coping strategies.

community Any long term positive experiences with just minoxidil plus a dermaroller?

in Minoxidil 10 upvotes 8 months ago

Minoxidil and dermarolling can yield positive hair growth results, but long-term effectiveness varies, and some users experience hair loss again without additional treatments like finasteride. Microneedling enhances minoxidil's effectiveness by increasing enzyme activity, but individual experiences differ.

community Seeking advice from dut non-responders who used RU

in Update 1 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically the use of RU58841 by individuals who did not respond to dutasteride. Users share experiences with maintaining hair using RU58841 and mention trying pyrilutamide and the upcoming availability of pp405.

community Found a winning combo for a non/weak-responder

in Research/Science 4 upvotes 2 years ago

A user found a successful hair loss treatment using a combination of finasteride, dutasteride, minoxidil, and RU58841. They plan to switch to a purely topical regimen with finasteride, RU58841, and minoxidil.

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Learn

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learn Hair Transplant

What is shock loss after a hair transplant? Shock loss is temporary hair shedding after a transplant, usually resolving in a few months.

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