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Glossary Stem Cell Quiescence

state where stem cells remain inactive to preserve function

Stem cell quiescence, also known as stem cell dormancy, refers to a state in which stem cells remain inactive or non-dividing. This state helps protect the stem cells from exhaustion and damage, ensuring they can be activated when needed for tissue repair or regeneration. Quiescent stem cells are crucial for maintaining long-term tissue health and preventing premature aging or diseases like cancer.

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Research

5 / 1000+ results

research Stem cell quiescence acts as a tumour suppressor in squamous tumours

66 citations , December 2013 in “Nature Cell Biology”

This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.

research Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

40 citations , April 2014 in “Genes & Development”

The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.

research Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

In this study, researchers found that Gab1 is critical in controlling the hair cycle and the self-renewal of hair follicle stem cells in mice.

research Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State

31 citations , September 2013 in “Stem Cells”

This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.

research The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

2 citations , May 2022 in “Stem cell research & therapy”

This study found that hair follicle stem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.

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Community Join

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community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Relax to grow more hair. Study title: Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

6 upvotes 5 years ago

Relaxation may promote hair growth by reducing corticosterone, which affects hair follicle stem cells. Corticosteroids are used for alopecia areata, but their long-term use for androgenic alopecia is uncertain.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

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Learn

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learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor is a signalling protein linked to hair colour in lab and mouse studies; it is not a proven hair-loss treatment in people.
Does stem cell factor help activate dormant hair follicles? Lab and mouse studies link stem cell factor to hair colour; it has not been shown to reactivate dormant hair follicles in people.
Are stem cell factor products safe for long-term scalp use? Long-term safety of stem cell factor scalp products has not been studied in people; the one human trial of injected stem cell factor reported skin reactions and lasting dark patches.
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learn Apple stem cell

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