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Stem Cell Factor

also sh-Polypeptide-4, SCF, KIT-ligand, steel factor, mast cell growth factor

Protein crucial for stem cell survival and differentiation

Stem cell factor is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

Research 10

  1. Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair folliclesJournal of Endocrinology · 2008 · 50 citations
  2. 25th Annual meeting of the European Society for Pigment Cell Research, Marseille, FrancePigment Cell & Melanoma Research · 2024
  3. Fas and c-kit are Involved in the Control of Hair Follicle Melanocyte Apoptosis and Migration in Chemotherapy-Induced Hair LossJournal of Investigative Dermatology · 2003 · 68 citations
  4. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative InvestigationsACTA HISTOCHEMICA ET CYTOCHEMICA · 2010 · 18 citations
  5. Androgen actions on the human hair follicle: perspectivesExperimental Dermatology · 2012 · 196 citations
  6. Hair follicles serve as local reservoirs of skin mast cell precursorsBlood · 2003 · 93 citations
  7. Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cellseLife · 2020 · 38 citations
  8. Functional Characterization of Melanocyte Stem Cells in Hair FolliclesJournal of Investigative Dermatology · 2011 · 48 citations
  9. Dermal Papilla Cells Derived from Beard Hair Follicles Secrete More Stem Cell Factor (SCF) in Culture Than Scalp Cells or Dermal FibroblastsBiochemical and Biophysical Research Communications · 1996 · 61 citations
  10. Stem Cell Factor Combined with Matrix Proteins Regulates the Attachment and Migration of Melanocyte Precursors of Human Hair Follicles in VitroBiological and Pharmaceutical Bulletin · 2013 · 7 citations
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