Recent Advances on Skin-Resident Stem/Progenitor Cell Functions in Skin Regeneration, Aging, and Cancers and Novel Anti-Aging and Cancer Therapies

    September 2009 in “ Journal of Cellular and Molecular Medicine ”
    Murielle Mimeault, Surinder K. Batra
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    TLDR New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
    The document from 2010 reviewed the critical roles of skin-resident stem/progenitor cells in skin regeneration, aging, and cancer, and discussed potential novel therapies. It explained that damage to these cells from factors like UV radiation and oxidative stress can lead to skin diseases and cancer. The review highlighted the promise of treatments such as anti-inflammatory and antioxidant therapies, stem cell replacement, gene therapies, and targeting cancer stem/progenitor cells. It detailed the molecular events in skin aging and cancer progression and the potential of novel therapies to prevent or delay the decline of skin-resident stem/progenitor cells and to treat skin cancers by targeting the altered cells and their microenvironment. The document emphasized the importance of further research to understand these cells' specific functions in skin maintenance and regeneration after severe injuries.
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