TLDR New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
The document from 2010 reviewed the critical roles of skin-resident stem/progenitor cells in skin regeneration, aging, and cancer, and discussed potential novel therapies. It explained that damage to these cells from factors like UV radiation and oxidative stress can lead to skin diseases and cancer. The review highlighted the promise of treatments such as anti-inflammatory and antioxidant therapies, stem cell replacement, gene therapies, and targeting cancer stem/progenitor cells. It detailed the molecular events in skin aging and cancer progression and the potential of novel therapies to prevent or delay the decline of skin-resident stem/progenitor cells and to treat skin cancers by targeting the altered cells and their microenvironment. The document emphasized the importance of further research to understand these cells' specific functions in skin maintenance and regeneration after severe injuries.
Cited in this study
7 / 7 results
57 citations
,
April 2009 in “Differentiation” SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.
24 citations
,
March 2009 in “Clinical and experimental dermatology” Repigmentation in vitiligo may come from melanocyte stem cells in the skin.
70 citations
,
November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Notch/RBP-J signaling is crucial for proper placement and timing of melanocyte development in hair follicles.
35 citations
,
April 2008 in “Human Molecular Genetics” Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
550 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
417 citations
,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
December 2022 in “Journal of Investigative Dermatology” Aging in one type of stem cell can cause aging-like changes in various organs.
July 2007 in “Cancer biology & therapy” Removing a key gene in mice leads to premature aging and loss of stem cells.
