More Than One Way to Skin

April 2008 in “ Genes & Development ”

Elaine Fuchs, Valerie Horsley

epithelial stem cells epithelial–mesenchymal interactions epidermis hair follicle sebaceous gland stem cell niches signaling networks migration proliferation differentiation lineages skin diseases

TLDR Skin stem cells help repair damage and maintain healthy skin.

The document discussed how epithelial stem cells in the skin were specified during development through epithelial–mesenchymal interactions, allowing them to form the epidermis, hair follicle, and sebaceous gland. In adults, these stem cells maintained their own populations for self-renewal and tissue homeostasis. In response to injury, some stem cell niches could be mobilized to repair damaged epithelial tissues. The study explored how these stem cells responded to signaling networks, activated migration and proliferation, and differentiated along specific lineages. Understanding these processes was crucial, as defects could lead to skin diseases, including cancers.

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Research cited in this study

15 / 15 results

research Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells

415 citations , January 2008 in “Cell”

NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.

research Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

98 citations , August 2007 in “PLoS ONE”

Myc changes chromatin in stem cells, causing them to leave their niche.

research Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function

143 citations , May 2007 in “Proceedings of the National Academy of Sciences”

Vitamin D receptor is crucial for normal hair growth and preventing hair loss.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

147 citations , September 2006 in “Developmental Cell”

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations , June 2005 in “Genes & development”

β-catenin is essential for stem cell activation and proliferation in hair follicles.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 1 year ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 446 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community This is the best time in human history to be fighting hair loss

in Treatment 191 upvotes 3 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

Related Research

4 / 4 results

research Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice

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Lef1 is essential for normal skin, hair growth, and healing wounds in mice.

research Hair Follicle Bulge-Derived Stem Cells Promote Tissue Regeneration During Skin Expansion

27 citations , October 2020 in “Biomedicine & Pharmacotherapy”

Hair follicle stem cells help skin heal and grow better.

research Promoting Effect of Hair Follicle Stem Cells in the Wound Healing of Skin

December 2017 in “Chin J Cell Stem Cell (Electronic Edition)”

Hair follicle stem cells help skin wounds heal faster.

research Understanding the Functional Contribution of Dermal Stem Cells to Hair Follicle Regeneration and Skin Wound Healing

January 2017

Dermal stem cells help regenerate hair follicles and heal skin wounds.