Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice
July 2022
in “
Journal of Investigative Dermatology
”
Lef1 fibroblasts skin development hair development wound healing epigenetic landscape gene expression papillary fibroblasts hair follicle regeneration histological assessments wild-type Lef1 KO embryonic Lef1 expression neonatal Lef1 expression papillary lineage epigenetics histology Lef1 knockout embryonic Lef1 neonatal Lef1
Studysummary This study found that the transcription factor Lef1 is crucial for normal skin and hair development and wound healing, highlighting its role in regulating essential genes and pathways in papillary fibroblasts.
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