Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

    January 2016 in “ Development
    Emanuel Rognoni, Céline Gomez, Angela Oliveira Pisco, Emma L. Rawlins, Benjamin D. Simons, Fiona M. Watt, Ryan R. Driskell
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    TLDR Blocking β-catenin in skin cells improves hair growth during wound healing.
    The study found that inhibiting β-catenin signaling in dermal fibroblasts can enhance hair follicle regeneration during wound healing. The researchers used mice and found that β-catenin ablation in fibroblasts promoted hair follicle regeneration in neonatal and adult mouse wounds while β-catenin activation reduced hair follicle regeneration in neonatal wounds. The study suggests that inhibiting β-catenin signaling in dermal fibroblasts could be a potential therapeutic strategy for promoting hair growth and wound healing.
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