Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

July 2016 in “ Development ”

Emanuel Rognoni, Céline Gomez, Angela Oliveira Pisco, Emma L. Rawlins, Benjamin D. Simons, Fiona M. Watt, Ryan R. Driskell

TLDR Blocking β-catenin in skin cells improves hair growth during wound healing.

The study found that inhibiting β-catenin signaling in dermal fibroblasts can enhance hair follicle regeneration during wound healing. The researchers used mice and found that β-catenin ablation in fibroblasts promoted hair follicle regeneration in neonatal and adult mouse wounds while β-catenin activation reduced hair follicle regeneration in neonatal wounds. The study suggests that inhibiting β-catenin signaling in dermal fibroblasts could be a potential therapeutic strategy for promoting hair growth and wound healing.

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17 / 17 results

research Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation

32 citations , December 2015 in “Journal of Investigative Dermatology”

Prominin-1 expressing cells in the dermal papilla help regulate hair follicle size and communication but don't aid in skin repair.

research Defining Dermal Adipose Tissue

218 citations , September 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin

24 citations , June 2012 in “Developmental Biology”

Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , April 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations , April 2012 in “Journal of Investigative Dermatology”

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations , December 2011 in “Development”

Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Neogenesis of Human Hair Follicles

13 citations , December 2006 in “Annals of the New York Academy of Sciences”

Human hair follicles can grow back.

5 / 5 results

research Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice

August 2022 in “Journal of Investigative Dermatology”

Lef1 is essential for normal skin, hair growth, and healing wounds in mice.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations , November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations , July 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , April 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

Cited in this study

research Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation

research Defining Dermal Adipose Tissue

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

research Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

research Review of Hair Follicle Dermal Cells

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research Neogenesis of Human Hair Follicles

research An In Vivo Mouse Excisional Wound Model of Scarless Healing

research Molecular Principles of Hair Follicle Induction and Morphogenesis

research Molecular Mechanisms Regulating Hair Follicle Development

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research Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair