Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin
October 2011
in “
Development
”
β-catenin hair follicle density subcutaneous adipose tissue dermal fibroblasts ectopic hair follicles telogen dermis anagen dermis epidermis neonatal dermis skin aging hair loss beta-catenin hair follicles fat tissue skin cells new hair follicles resting phase skin growth phase skin skin surface newborn skin
TLDR Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
In 2011, researchers investigated the potential of β-catenin, a protein, in rejuvenating adult skin to a neonatal state. They activated β-catenin in the epidermis of adult mice, which led to the dermis reverting to a neonatal state, characterized by increased hair follicle density and subcutaneous adipose tissue. The study also examined the properties of dermal fibroblasts, crucial in hair follicle formation, and found that adult dermis with ectopic hair follicles resembled neonatal dermis more than adult telogen or anagen dermis. The researchers concluded that adult dermis can be reprogrammed to acquire the characteristics of neonatal dermis in response to cues from the overlying epidermis, suggesting potential therapeutic interventions in skin aging and disorders, including hair loss.