Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling

December 2008 in “ Developmental biology ”

Charlotte Collins, Fiona M. Watt

retinoic acid-binding proteins CRABP1 CRABP2 FABP5 β-catenin Notch signaling dermal papilla sebaceous glands interfollicular epidermis hair follicles RA treatment Wnt/β-catenin signaling Notch activation RA signaling retinoic acid RA

TLDR Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

The study investigated the dynamic regulation of retinoic acid-binding proteins (CRABP1, CRABP2, and FABP5) in developing, adult, and neoplastic skin, revealing their regulation by β-catenin and Notch signaling. CRABP1 was found in the dermal papilla and tumor stroma, while CRABP2 and FABP5 were expressed in sebaceous glands, interfollicular epidermis, and hair follicles. RA treatment increased the expression of these proteins, while Wnt/β-catenin signaling downregulated them. Notch activation increased CRABP2 and FABP5 in the interfollicular epidermis but not in hair follicles. The study highlighted the complex regulation of RA signaling in skin and its interaction with β-catenin and Notch pathways, suggesting potential therapeutic targets for skin-related conditions.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment

25 citations, March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations, January 2008 in “PloS one”

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations, September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled

127 citations, July 2002 in “EMBO journal”

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Related Community Posts Join

6 / 100 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I’m already DOING EVERYTHING!!!

in Female 27 upvotes 3 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

community Tretinoin aka retinoic acid, the minoxidil enhancer

in Product 8 upvotes 9 months ago

Tretinoin can make minoxidil more effective for hair loss treatment, but some users did not see improved hair density with this combination and had better results with dutasteride.

community New Product from Minoxidil Max - Topical Retinoic Acid (Tretinoin) is available now

in Minoxidil 7 upvotes 3 years ago

A new product, a retinoic acid solution (0.3%), is available to enhance minoxidil products like Rogaine and Kirkland by converting them into a tretinoin-containing solution for improved hair loss treatment. One unit of the product is enough for a year's supply.

community Just got my Dualgen-5R, the one with retinoic acid (tretinoin) but without the fin.

in Minoxidil 6 upvotes 3 years ago

The user has been using Minoxidil and finasteride with success and is now trying Dualgen-5R with retinoic acid but without finasteride, along with microneedling. They plan to share results in 5-6 months.

community How important are Retinoic and Hydrocortisone in topical serum?

in Treatment 4 upvotes 2 weeks ago

The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

Similar Research

5 / 1000+ results

research Skin Fibroblast Functional Heterogeneity in Health and Disease

1 citations, August 2023 in “The Journal of Pathology”

Different types of skin fibroblasts have unique roles in skin health and disease.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing

128 citations, August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

130 citations, March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Vitamin A in Skin and Hair: An Update

14 citations, July 2022 in “Nutrients”

Vitamin A is important for healthy skin and hair, influencing hair growth and skin healing, but UV light reduces its levels.

research Effects of All-Trans Retinoic Acid on Goat Dermal Papilla Cells Cultured In Vitro

4 citations, May 2018 in “Electronic Journal of Biotechnology”

All-trans retinoic acid at high doses harms goat hair growth cells and could be bad for hair growth.