TLDR The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
The 2007 document reviews the development of the skin and its appendages, particularly focusing on the role of stem cells in hair follicle regeneration and wound healing. It discusses the origin of the epidermis and its structures from multipotent embryonic progenitor keratinocytes and the importance of signaling pathways such as Wnt, BMPs, FGFs, and Shh in skin epithelium fate determination and hair follicle morphogenesis. The review also covers the differentiation of hair follicle layers, the hair growth cycle, and the maintenance of follicle stem cells, emphasizing the balance of c-myc expression to prevent alopecia. It highlights the roles of c-Myc and LHX2 in follicle stem cell maintenance, BLIMP1 in sebaceous gland development, and the importance of epidermal homeostasis. The document concludes by discussing the potential of skin stem cells in regenerative medicine and the implications for treating various conditions. It is a summary of multiple research findings and does not provide specific numbers of study participants.
Cited in this study
9 / 9 results
550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
291 citations
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October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
479 citations
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January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
165 citations
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September 2001 in “Genes & development” CDP is crucial for lung and hair follicle cell development.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
1113 citations
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
30 citations
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May 2018 in “Experimental Dermatology” The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.
41 citations
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June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
85 citations
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July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.