TLDR Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
This study demonstrated that adult stem cells from rat whisker follicles were clonogenic and multipotent, capable of generating all hair follicle and sebaceous gland lineages after over 140 doublings in culture. When transplanted into newborn mouse skin, these stem cells contributed to developing follicles, with thousands of follicles arising from a single stem cell's progeny. The cultured stem cells expressed self-renewal genes Bmi1 and Zfp145, and multiple stem cells were involved in forming a single hair bulb. The findings also revealed a higher number of stem cells in whisker follicles than previously estimated.
421 citations
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September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
561 citations
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April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
1 citations
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October 2012 in “Elsevier eBooks” Skin stem cells can help improve skin repair and regeneration.
207 citations
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July 2006 in “Development” MTS24 marks a new type of skin cell that helps hair growth and repair.
120 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
65 citations
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November 2012 in “Tissue Engineering Part B-reviews” Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.
