TLDR Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
The document from February 1, 2007, reviews the critical role of epithelial stem cells in tissue self-renewal, development, and repair, and the common signaling pathways, such as Wnt/ß-catenin and Notch, that regulate these processes across various epithelia. It discusses the identification of these stem cells using label-retaining techniques and the development of a method to mark and isolate living label-retaining cells (LRCs) in transgenic mice. The multipotency of epithelial stem cells is exemplified by their ability to differentiate into multiple lineages in the hair follicle and mammary gland. The review also highlights the potential of epithelial stem cells in regenerative medicine, such as treating burns and blindness, and underscores the importance of understanding their behavior to develop treatments for epithelial tissue damage and cancer.
291 citations,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
384 citations,
June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
211 citations,
October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
19 citations,
April 2015 in “Developmental Dynamics” The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
36 citations,
September 2009 in “Journal of Cellular and Molecular Medicine” New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
48 citations,
July 2008 in “Acta Biochimica et Biophysica Sinica” Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
105 citations,
October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
10 citations,
June 2016 in “Wound Repair and Regeneration” The microenvironment, especially mechanical forces, plays a crucial role in hair growth and could lead to new treatments for hair loss.
