TLDR Understanding stem cell interactions with their environments is key for advancing regenerative medicine.
The document "Stem Cells and Their Niches" discussed the critical role of stem cells and their microenvironments, or niches, in maintaining tissue homeostasis and regeneration. It highlighted how stem cells interact with their niches to regulate their self-renewal and differentiation. The study emphasized the importance of understanding these interactions to harness stem cells' potential for therapeutic applications. The authors, Kateri A. Moore and Ihor R. Lemischka, provided insights into the molecular and cellular mechanisms governing stem cell behavior within their niches, which was crucial for advancing regenerative medicine.
1279 citations
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November 2005 in “Nature Medicine” 
291 citations
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October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
417 citations
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September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
414 citations
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August 2005 in “Nature” Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
335 citations
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March 2004 in “Development” Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.
250 citations
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November 2003 in “The Journal of Cell Biology” BMP receptor IA is essential for proper hair cell differentiation in mice.
421 citations
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September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
