Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

    September 2005 in “ PLoS biology ”
    Michael Rendl, Lisa E. Lewis, Elaine Fuchs
    Image of study
    TLDR Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
    The study investigated the molecular interactions between mesenchymal dermal papilla (DP) cells and epithelial stem cells in hair follicle formation and growth. Using a novel multicolor labeling approach with transgenic expression of fluorescent proteins and immunolabeling, researchers isolated pure populations of DP and surrounding cell types. They defined transcriptional profiles to develop molecular signatures characteristic of the DP niche, identifying genes linked to hair disorders and novel signaling regulators. These findings provided a foundation for future functional analyses of these genes in hair development and illustrated how understanding gene expression in complex niches can reveal insights into tissue biology and disease.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 13 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Comprehensive Microneedling Guide

      in Microneedling  289 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

    Related Research

    1 / 1 results