Primary Cell Culture and Morphological Characterization of Canine Dermal Papilla Cells and Dermal Fibroblasts

February 2002 in “ Veterinary Dermatology ”

Christine B. Bratka‐Robia, Gerda Mitteregger, Amanda Aichinger, Monika Egerbacher, M. Helmreich, E. Bamberg

dermal papilla cells dermal fibroblasts primary hair follicles Amniomax complete C100 medium collagen IV laminin

Studysummary This study reported that canine dermal papilla cells showed a distinct growth pattern and strong collagen IV and laminin staining compared to dermal fibroblasts.

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Research cited in this study

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research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that while both beard and scalp dermal papilla cells release similar autocrine growth factors, only beard cells increased production and response with testosterone, suggesting these factors enhance androgen-induced hair growth.

research Cultured Dermal Papilla Cells of the Rat Vibrissa Follicle: Proliferative Activity, Adhesion Properties, and Reorganization of the Extracellular Matrix In Vitro

27 citations , December 1997 in “Archives of Dermatological Research”

This study observed that cultured dermal papilla cells showed distinct functional properties from dermal fibroblasts, including lower proliferation rates, higher adhesion to collagen type IV, and different cell-matrix interactions.

research Serum-Free Culture of Wool Follicles: Effects of Nutrients, Growth Factors, and Hormones

11 citations , October 1997 in “British Journal of Dermatology”

This study found that a serum-free culture system supported hair growth from follicles responsive to calcium, glucose, and amino acids, with insulin enhancing the growth, while other factors had no effect.

research The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology

19 citations , October 1996 in “Dermatologic Clinics”

This review discusses using cultured dermal papilla cells to investigate hair follicle biology, emphasizing their potential to inform treatments, but reports no new clinical results.

research Human Hair Follicle Dermal Papilla Cell, Dermal Sheath Cell, and Interstitial Dermal Fibroblast Characteristics

36 citations , September 1996 in “PubMed”

This study found that dermal papilla and dermal sheath cells from human scalp tissue differ from interstitial dermal fibroblasts in morphology and produce varying levels of TGF-beta 2.

research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

37 citations , June 1996 in “Journal of cellular physiology”

This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.

research Hair Follicle Proteoglycans

44 citations , July 1993 in “Journal of Investigative Dermatology”

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

9 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the in vitro growth of hair follicle cells, particularly papilla cells and outer root sheath keratinocytes, is influenced by different concentrations of androgens and antiandrogens.

Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

12 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.

research Hormones and Hair Growth: Variations in Androgen Receptor Content of Dermal Papilla Cells Cultured from Human and Red Deer Hair Follicles

34 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that androgens influence hair follicle behavior via the dermal papilla, using evidence from human and red deer cells with differing androgen responses as models.

research Expression of Basement Membrane Proteins and Interstitial Collagens in Dermal Papillae of Human Hair Follicles

85 citations , January 1991 in “Journal of Investigative Dermatology”

research In Vitro Effects of Testosterone, Dihydrotestosterone, and Estradiol on Cell Growth of Human Hair Bulb Papilla Cells and Hair Root Sheath Fibroblasts

22 citations , July 1990 in “Acta Dermato Venereologica”

In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

106 citations , April 1986 in “British Journal of Dermatology”

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.