TLDR Wool follicles grew fibres for 8-10 days in a serum-free culture, influenced by calcium, glucose, amino acids, and insulin.
A serum-free culture system enabled wool follicles to grow fibres for 8-10 days, with growth influenced by calcium, glucose, amino acids, and stimulated by insulin (10 µg/mL). Conditioned media from dermal papilla cells, mitomycin-treated dermal papilla cells, thyroid hormones, and hydrocortisone had no effect on fibre growth. Morphological changes in the follicle bulb accompanied the decline in fibre growth, which was not due to oxidative damage as antioxidants did not improve growth rate or longevity. This model was useful for studying the direct effects of various factors on fibre growth and follicle metabolism.
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