TLDR Wool follicles grew fibres for 8-10 days in a serum-free culture, influenced by calcium, glucose, amino acids, and insulin.
A serum-free culture system enabled wool follicles to grow fibres for 8-10 days, with growth influenced by calcium, glucose, amino acids, and stimulated by insulin (10 µg/mL). Conditioned media from dermal papilla cells, mitomycin-treated dermal papilla cells, thyroid hormones, and hydrocortisone had no effect on fibre growth. Morphological changes in the follicle bulb accompanied the decline in fibre growth, which was not due to oxidative damage as antioxidants did not improve growth rate or longevity. This model was useful for studying the direct effects of various factors on fibre growth and follicle metabolism.
173 citations,
July 1995 in “Biochemical and biophysical research communications” Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
20 citations,
February 1994 in “In vitro cellular & developmental biology. Animal” Wool follicles can grow in a lab with the right nutrients and conditions.
68 citations,
December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
8 citations,
April 1965 in “Archives of biochemistry and biophysics” Sheep wool follicles can metabolize both glucose and acetate using different pathways important for wool growth.
4 citations,
July 2022 in “Journal of Cosmetic Dermatology” Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.
17 citations,
February 2015 in “International Journal of Molecular Sciences” A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.
